Generic Name: Clomiphene
Indications: Prescribed to promote ovulation – the release of mature eggs – to increase the likelihood of pregnancy.
FDA Drug Category: X

Summary Recommendations: Serophene is a fertility drug commonly prescribed to women as part of fertility treatment. The drug is typically prescribed for a 5-day cycle. Always take Serophene as prescribed.

General Precautions: Serophene stimulates ovulation – the release of mature eggs ready to be fertilized. In some cases more than one egg may be released. It is important to speak with your physician about the chances of conceiving multiples before starting a Serophene cycle.

Serophene is contraindicated (or may need to be dosed differently) in patients with thyroid problems, liver disease, uterine fibroids or ovarian cysts. Your doctor may be able to lower the dose to reduce the risk of side effects.

Taking Serophene increases the risk of ovarian hyperstimulation syndrome, known as OHSS. If you experience hand or leg swelling, pain in the abdomen or difficulty breathing, speak with your doctor immediately. The condition can be life-threatening.

Effects While Trying to Conceive: Serophene stimulates the maturation and release of eggs in the female body – ovulation. As such, the drug increasing chances of pregnancy thus improving fertility for some patients. Clomid may also be prescribed to male patients under the care of a fertility specialist.

Effects on Pregnancy: Serophene is dangerous to the fetus. The Food and Drug Administration has placed the drug in category X, the most dangerous drug category. Serophene is typically prescribed as part of a fertility plan. It is important to follow the fertility plan to reduce the risk of getting pregnant while taking the drug. If you find out you are pregnant while taking Serophene, contact the prescribing physician immediately as the drug can cause fetal defect and genetic complications.

Serophene has been associated with congenital heart problems, club foot, conjoined twins, syndactyly, hernia and ichthyosis. There have also been reports of genetic anomalies including dwarfism, Down’s syndrome, developmental delay and other chromosome-related disorders.

Safe During Breastfeeding: Serophene levels have not been tested in human breast milk, but animal studies show the drug is excreted in breast milk. Serophene may hinder lactation making it difficult to breastfeed while taking the drug. If you are breastfeeding and wish to take Serophene to improve your chances of getting pregnant, speak with your doctor about possible implications. Some women choose to wait until they stop breastfeeding to take Serophene. There have been no reports of negative side effects associated with taking Serophene while breastfeeding.

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