What is Sex Hormone Binding Globulin?
The test for sex hormone binding globulin (SHBG) levels is typically reserved for men. The globulin binds to androgens, or hormones found in men. As men age, testosterone levels tend to fall dramatically, leading to reduced muscle tone, sex drive and energy. The SHBG test is often paired with other hormone-related blood tests to give the physician an overall look at the androgen picture.

In women, SHBG levels rise during pregnancy and when a woman suffers from polycystic ovarian syndrome. The syndrome causes increased male characteristics like facial hair growth and cessation of normal menstrual cycle. Women with excessive SHBG may also suffer from infertility.

Normal Value Range

• Negative Pregnancy Adult: 2 to 12.8 µg/dL or 18 to 114 mmol/L
• Pregnancy Trimester One: 4.4 to 14.7 µg/dL or 39 to 131 mmol/L
• Pregnancy Trimester Two: 24 to 81 µg/dL or 214 to 717 mmol/L
• Pregnancy Trimester Three: 24 to 81.3 µg/dL or 216 to 724 mmol/L

< Laboratory Values During Pregnancy